Relationship between perioperative medications and risk of emergence agitation in children after sevoflurane… | ScholarDeck

Paper

Relationship between perioperative medications and risk of emergence agitation in children after sevoflurane anesthesia: a network meta-analysis.

New research · Anesthesiology

Pediatric research · 3w

Systematic reviewPediatric research· Jan 2026

Relationship between perioperative medications and risk of emergence agitation in children after sevoflurane anesthesia: a network meta-analysis.

Saihao Fu, Mengrong Miao, Jing Bian … Mingyang Sun

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Perioperative MedicineSystematic reviewTreatmentQ1IF 3.1

Dexmedetomidine strongly reduced emergence agitation risk after sevoflurane anesthesia in children.

Relationship between perioperative medications and risk of emergence agitation in children after sevoflurane anesthesia: a network meta-analysis.

Saihao Fu … Mingyang Sun

Pediatric research · Jan 2026

Purpose

To explore the efficacy of perioperative medications in preventing emergence agitation (emergence agitation) in children after sevoflurane anaesthesia.

Methods

This network meta-analysis used a frequency-analysis model.

n = 7617 participants

Results

dexmedetomidine cut emergence agitation risk far more than placebo

OR by subgroup · 95% CI

More results

In the cumulative ranking area under the curve (SUCRA) analysis, sufentanil, esketamine, dexmedetomidine, nalbuphine, tropisetron, ketamine, magnesium sulphate, propofol, fentanyl, remifentanil, and midazolam showed significant emergence agitation-preventing effects.

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Conclusion

Dexmedetomidine, propofol, midazolam, fentanyl, nalbuphine, and ketamine showed favourable emergence agitation-preventing effects in children.

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