Association of the dose of maternal general anaesthesia during Caesarean delivery with 5-minute Apgar scores: a retrospective single centre cohort study.

In this cohort of preterm, late preterm, and term neonates delivered via planned CD or Caesarean hysterectomy, total general anaesthetic dose was statistically associated with the 5-min Apgar score, although the clinical effect was modest.

The attenuation of the EMAC-AUC association after adjusting for MAP80AUC suggests that maternal hypotension may play an important explanatory role, although causality cannot be inferred.