Menstrual Disorder Frequency Across Ibuprofen and Oral Contraceptive Treatment Modalities in…

Cross-sectionalWomen's health reports (New Rochelle, N.Y.)· 2026

Menstrual Disorder Frequency Across Ibuprofen and Oral Contraceptive Treatment Modalities in Reproductive-Age Women: A Population-Based Analysis Using the NIH All of Us Research Program.

Quinn Fan, Mika Allyssa A Esquillo, Christina M Seeger, Paul W Zarutskie

Family Planning & ContraceptionCross-sectionalQ2IF 1.4

Oral contraceptives linked to less dysmenorrhea than ibuprofen plus oral contraceptives in women 25-35.

Menstrual Disorder Frequency Across Ibuprofen and Oral Contraceptive Treatment Modalities in Reproductive-Age Women: A Population-Based Analysis Using the NIH All of Us Research Program.

Quinn Fan … Paul W Zarutskie

Women's health reports (New Rochelle, N.Y.) · 2026 · Q2 in Obstetrics & Gynecology

Background

Despite the widespread use of nonsteroidal anti-inflammatory drugs and oral contraceptives (oral contraceptives), population-level analyses on how menstrual disorder diagnoses vary across ibuprofen and oral contraceptives use remain limited.

Methods

Were stratified into ages 18-24 and 25-35 years and grouped by recorded ibuprofen only, oral contraceptives only, or ibuprofen + oral contraceptives exposure.

n = 2832

Results

1.4%

1.4 percentage points lower dysmenorrhea prevalence with oral contraceptives alone versus combined use.

n = 2832

More results

In women aged 18-24 years, no significant differences in diagnosis prevalence were observed between treatment groups (ibuprofen: n = 2832; oral contraceptives: n = 4256; and combination: n = 2315).

More results

Between-group prevalence differences were modest (0.9 to 2.1 percentage points) and did not remain significant after Holm-Bonferroni correction (all Holm-Bonferroni adjusted p > 0.05).

Irregular menstruation was more frequent in the oral contraceptives group than in the ibuprofen group (2.1%; Holm-Bonferroni-adjusted p < 0.05).

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Conclusion · 1 of 2

Menstrual disorder diagnosis frequencies differed across ibuprofen and oral contraceptives exposure groups, primarily among women 25-35 years old.

Conclusion · 2 of 2

Longitudinal studies with untreated comparators and better characterizations of treatment timing, dose, and duration are needed.

Menstrual Disorder Frequency Across Ibuprofen and Oral Contraceptive Treatment Modalities in Reproductive-Age Women: A Population-Based Analysis Using the NIH All of Us Research Program.

Menstrual Disorder Frequency Across Ibuprofen and Oral Contraceptive Treatment Modalities in Reproductive-Age Women: A Population-Based Analysis Using the NIH All of Us Research Program.

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