Efficacy of a probiotic formula in the management of menopausal symptoms and quality of life: a randomized…

Randomized trialMenopause (New York, N.Y.)· Aug 2026

Efficacy of a probiotic formula in the management of menopausal symptoms and quality of life: a randomized controlled trial.

María Rodríguez-Palmero, Claudia Prat, Xavier Molina … Silvia P González

Menopause & Hormone TherapyRandomized trialTreatmentQ1IF 3.1

Probiotic reduced menopause symptom severity more than placebo over 3 months

Efficacy of a probiotic formula in the management of menopausal symptoms and quality of life: a randomized controlled trial.

María Rodríguez-Palmero … Silvia P González

Menopause (New York, N.Y.) · Aug 2026 · Q1 in Obstetrics & Gynecology

Purpose

Estrogen decline during menopause transition is associated with physical and psychological symptoms that impair overall well-being.

Methods

We conducted a decentralized, randomized, double-blind, placebo-controlled trial using a real-world approach.

n = 160

-1.00

Results

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symptom score improved more with the probiotic than placebo

n = 160

More results

Per-protocol analysis also revealed differences in the psychological domain between groups, favoring the probiotic (-0.51 [0.25], P=0.040).

Cervantes scale showed no significant differences between groups, but the change in Utian Quality of Life score was significantly higher in the probiotic group (2.21 [1.07], P=0.040).

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Conclusion · 1 of 2

In this real-world study, the probiotic formula was associated with improvements in menopause-associated symptoms and quality of life, whereas the global Cervantes score appeared to be similar between groups.

Conclusion · 2 of 2

Future investigations are required to confirm this clinical effect and the underlying mechanisms of action. ClinicalTrials.gov identifier: NCT06604234.

Efficacy of a probiotic formula in the management of menopausal symptoms and quality of life: a randomized controlled trial.

Efficacy of a probiotic formula in the management of menopausal symptoms and quality of life: a randomized controlled trial.

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