Long-term risk of gynecologic malignancies in postmenopausal women with vaginal bleeding and benign endometrial lesions: a cohort study.

The initial diagnosis rates of endometrial malignancy and precancerous lesions were 15.1% (105/696) and 2.9% (20/696), respectively.

Among the 118 patients with initially benign endometrial pathology, 5.1% (6/118) and 7.6% (9/118) were diagnosed with malignancy and precancerous lesions, respectively, within 3 months of initial evaluation.

High-grade serous carcinoma constituted a significantly higher proportion of malignancies detected during follow-up (43.8%) than of those diagnosed initially (6.5%; P < 0.001).