Association between glucose and lipid metabolism-related indicators and the occurrence and severity of…

Cohort studyFrontiers in medicine· 2026

Association between glucose and lipid metabolism-related indicators and the occurrence and severity of pelvic organ prolapse in postmenopausal women.

Dawei Cui, Mengjie Yang, Can Cui … Xin Luo

UrogynecologyCohort studyPrognosisQ1IF 3.4

Glucose-lipid metabolism score predicts pelvic organ prolapse risk with moderate accuracy

Association between glucose and lipid metabolism-related indicators and the occurrence and severity of pelvic organ prolapse in postmenopausal women.

Dawei Cui … Xin Luo

Frontiers in medicine · 2026 · Q1 in General Medicine

Background

Studies have shown that the occurrence of pelvic organ prolapse (prolapse) is associated with abnormalities in collagen, while glucose and lipid metabolism have also been proven to be related to collagen; however, their relationships with the risk and severity of prolapse remain unclear.

Methods

This retrospective study included 280 postmenopausal women, among whom 118 were in the prolapse group and 162 were in the non-prolapse group.

Results

higher score means a moderate ability to predict who develops prolapse, above chance

OR by subgroup · 95% CI

More results

FPG (OR = 1.028, 95%CI: 1.004-1.052, p = 0.023), HbA1c (OR = 1.073, 95%CI: 1.036-1.111, p < 0.001), TG (OR = 1.074, 95%CI: 1.003-1.149, p = 0.041), and LDL (OR = 1.069, 95%CI: 1.015-1.126, p = 0.012) were independent risk factors, whereas 25(OH)D was a protective factor.

More results

These associations remained significant after adjusting for confounding factors.

In addition, there was a significant interaction between the prediction model and age (OR = 1.048, 95%CI: 1.005-1.093, p = 0.028).

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Conclusion

The prediction model based on glucose and lipid metabolism constructed in this study can effectively assess the risk and severity of prolapse.

Association between glucose and lipid metabolism-related indicators and the occurrence and severity of pelvic organ prolapse in postmenopausal women.

Association between glucose and lipid metabolism-related indicators and the occurrence and severity of pelvic organ prolapse in postmenopausal women.

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