Folic acid supplementation and observed clinical outcomes in pediatric primary monosymptomatic nocturnal…

Cohort studyFrontiers in pediatrics· 2026

Folic acid supplementation and observed clinical outcomes in pediatric primary monosymptomatic nocturnal enuresis: a prospective single-arm cohort study from Gaza (2023-2025).

Sharif Jamal Salha, Madleen Jawad Abu Aser, Jadallah Okasha … Fahema Imad Jamil Obaid

Child Development & BehaviourCohort studyTreatmentQ1IF 2.2

42% of children with monosymptomatic nocturnal enuresis achieved complete remission after treatment

Folic acid supplementation and observed clinical outcomes in pediatric primary monosymptomatic nocturnal enuresis: a prospective single-arm cohort study from Gaza (2023-2025).

Sharif Jamal Salha … Fahema Imad Jamil Obaid

Frontiers in pediatrics · 2026 · Q1 in Pediatrics

Background

Primary monosymptomatic nocturnal enuresis (primary monosymptomatic nocturnal enuresis) is a common pediatric condition characterized by involuntary nighttime urination with high spontaneous remission rates.

Purpose

To describe observed changes in primary monosymptomatic nocturnal enuresis frequency following folic acid supplementation combined with behavioral therapy.

Methods

A prospective single-arm cohort study was conducted in Gaza (2023-2025).

n = 612 children

Results

over 4 in 10 became completely dry at night

MD 3.20 (95% CI 3 to 3.40)

null 0

3

3.40

CI excludes the null - significant

More results

Mean enuresis frequency decreased from 5.7 ± 1.2 to 2.4 ± 1.1 episodes/week (mean difference: 3.2; 95% CI: 3.0-3.4; p < 0.001; Cohen's dz = 2.78).

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Conclusion

A reduction in primary monosymptomatic nocturnal enuresis frequency was observed; however, causal inference cannot be established due to the uncontrolled design and confounding factors.

Folic acid supplementation and observed clinical outcomes in pediatric primary monosymptomatic nocturnal enuresis: a prospective single-arm cohort study from Gaza (2023-2025).

Folic acid supplementation and observed clinical outcomes in pediatric primary monosymptomatic nocturnal enuresis: a prospective single-arm cohort study from Gaza (2023-2025).

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