Delphi Consensus of the Italian Society of Pediatric Allergy and Immunology (SIAIP) on the management of…

StudyMultidisciplinary respiratory medicine· Jul 2026

Delphi Consensus of the Italian Society of Pediatric Allergy and Immunology (SIAIP) on the management of severe asthma in children and adolescents.

Michele Miraglia Del Giudice, Gianluigi Marseglia, Sara Manti … Amelia Licari

Pediatric RespiratoryStudyClinical practiceQ3IF 1.3

All 27 Delphi statements on severe pediatric asthma management reached expert consensus

Delphi Consensus of the Italian Society of Pediatric Allergy and Immunology (SIAIP) on the management of severe asthma in children and adolescents.

Michele Miraglia Del Giudice … Amelia Licari

Multidisciplinary respiratory medicine · Jul 2026

Background

Despite major advances in biological therapies, standardized guidance for their optimal use in children and adolescents remains limited.

Purpose

To establish experts' consensus on the management of severe pediatric asthma through a Delphi process promoted by the Italian Society of Pediatric Allergy and Immunology (SIAIP), with particular focus on biological therapy selection, monitoring, and response assessment.

Methods

A modified Delphi process involving 50 pediatric asthma experts was conducted.

n = 50 pediatric asthma experts

82-100%

Results

82-100%

experts agreed on all 27 recommendations, none fell short of consensus

n = 50 pediatric asthma experts

More results

Strong consensus also supported the use of Core Outcome Measures for Severe Asthma (Core Outcome Measures for Severe Asthma) for monitoring, classification of responders/super-responders /non-responders, and the predictive value of selected biomarkers, including blood eosinophil counts (≥300 cells/µL), FeNO, and baseline oral corticosteroid dose.

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Conclusion

This Delphi Consensus provides expert-endorsed, evidence-based recommendations for the management of severe pediatric asthma, emphasizing personalized selection of biological therapy guided by biomarkers and systematic response monitoring using standardized outcome measures.

Delphi Consensus of the Italian Society of Pediatric Allergy and Immunology (SIAIP) on the management of severe asthma in children and adolescents.

Delphi Consensus of the Italian Society of Pediatric Allergy and Immunology (SIAIP) on the management of severe asthma in children and adolescents.

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