Analysis of Risk Factors and Development of a Predictive Nomogram for Bronchiolitis Obliterans in Children With Severe Adenovirus Pneumonia: A Retrospective Study.
Nomogram accurately predicts bronchiolitis obliterans risk in children with severe adenovirus pneumonia
Analysis of Risk Factors and Development of a Predictive Nomogram for Bronchiolitis Obliterans in Children With Severe Adenovirus Pneumonia: A Retrospective Study.
Bronchiolitis obliterans (bronchiolitis obliterans) is a rare chronic pulmonary condition in pediatric patients, characterized by irreversible fibrotic constriction of the small airways.
This study aims to analyze the risk factors for bronchiolitis obliterans caused by severe adenovirus pneumonia (severe adenovirus pneumonia) and to develop a nomogram model for personalized prediction.
We retrospectively analyzed 251 children with severe adenovirus pneumonia admitted to the Children's Hospital of Nanjing Medical University between January 2017 and March 2024.
correctly distinguishes future bronchiolitis obliterans cases most of the time
Multivariable analysis identified the following independent risk factors for bronchiolitis obliterans: wheezing (odds ratio [OR] = 4.78; 95% confidence interval [CI], (2.00∼11.40); p < 0.001), large lobar consolidation (OR = 8.53; 95% CI, 3.63∼20.02; p < 0.001), length of hospital stay (OR = 1.20; 95% CI, 1.08-1.33; p < 0.001), and duration of fever (OR = 1.20; 95% CI, 1.09-1.32; p < 0.001).
Mechanical ventilation showed a trend toward increased risk but did not reach statistical significance (OR = 5.35; 95% CI, 0.74-38.56; p = 0.096).
Calibration curves indicated good agreement between predicted and observed outcomes.
A nomogram incorporating five independent risk factors-wheezing, duration of fever, length of hospital stay, mechanical ventilation, and large lobar consolidation-was developed to predict bronchiolitis obliterans risk in children with severe adenovirus pneumonia.