Treatment outcome in pediatric patients with T-ALL in Brazil.

Cohort studyLeukemia research· Jul 2026

Treatment outcome in pediatric patients with T-ALL in Brazil.

Ana Maria Marinho da Silva, Valdenizia R Silva, Alython Araújo Chung-Filho … Eugênia Terra-Granado

Read paper

Pediatric Hematology & OncologyCohort studyTreatmentQ2IF 1.9

5-year overall survival for pediatric T-ALL in Brazil was 47%.

Treatment outcome in pediatric patients with T-ALL in Brazil.

Ana Maria Marinho da Silva … Eugênia Terra-Granado

Leukemia research · Jul 2026

Background

Several studies conducted in high-income countries (high-income countries) have demonstrated that treatment intensification in pediatric T-cell acute lymphoblastic leukemia (T-ALL) improved survival outcomes.

Methods

Clinical, demographic, and laboratory variables were collected through a retrospective analysis of medical records.

n = 86 patients

Results

under half of children with T-ALL survived 5 years, far below high-income countries

70%

GBTLI-HR

35%

ALL IC-BFM 2002-HR

32%

ALL IC-BFM 2009-HR

More results

In both bivariate and multivariate analyses, the presence of adenomegaly at diagnosis was associated with lower OS and EFS.

In addition, the GBTLI-HR protocol achieved the highest OS (70.0%), compared to the 35.0% and 32.0% observed with the ALL IC-BFM 2002-HR and ALL IC-BFM 2009-HR protocols, respectively.

More results

This reinforces the need for context-specific adaptations of intensive treatment protocols in low- and middle-income countries.

“

Conclusion

This study offers valuable insights into the clinical and demographic characteristics of patients with T-ALL from Brazil, highlighting substantially higher mortality rates than those reported in high-income countries, primarily attributed to high infection rates.

Treatment outcome in pediatric patients with T-ALL in Brazil.

Treatment outcome in pediatric patients with T-ALL in Brazil.

Related papers