Evaluating Cardiotoxicity and Factors Associated with In-Hospital Mortality Among Emergency Department…

ObservationalSultan Qaboos University medical journal· 2026

Evaluating Cardiotoxicity and Factors Associated with In-Hospital Mortality Among Emergency Department Patients with Substance Use Disorder: An 11-year retrospective study .

Darpanarayan Hazra, Nadia Ahmed Said Alqusaimi, Alyaqeen Ahmed Abdullah Al Breiki … Suad Abdullah Al Abri

Substance & AddictionObservationalPrognosisQ3IF 0.8

Hypokinesia on echocardiography linked to over 5-fold higher odds of death in substance use disorder patients

Evaluating Cardiotoxicity and Factors Associated with In-Hospital Mortality Among Emergency Department Patients with Substance Use Disorder: An 11-year retrospective study .

Darpanarayan Hazra … Suad Abdullah Al Abri

Sultan Qaboos University medical journal · 2026 · Q3 in General Medicine

Background

Substance use disorder (substance use disorder)-related emergencies are increasing globally, with cardiotoxicity contributing substantially to morbidity and mortality.

Purpose

This study evaluated cardiotoxicity patterns and factors associated with in-hospital mortality among adults with substance use disorder presenting to the emergency department (emergency department).

Methods

This retrospective observational study was conducted from January 2014 to December 2024 at Sultan Qaboos University Hospital, University Medical City, Muscat, Oman.

n = 478 patients

Results

hypokinesia more than quintuples the odds of dying in hospital

OR 6.14 (95% CI 0.95 to 39.88)

null 1

0.95

39.88

CI crosses the null - not significant

More results

A total of 4,400 emergency department medical records were reviewed; 478 patients had substance use disorder and 78 (16.3%) met the inclusion criteria (mean age = 40.8 ± 12.3 years, 92.3% male).

Opiate-class positivity on urine drug screening was the most frequent finding (62.8%), followed by methamphetamine (29.5%).

More results

Sinus tachycardia (41.0%) and ST-T changes (15.4%) were the most common electrocardiographic abnormalities.

Overall, in-hospital mortality was 15.4%.

“

Conclusion · 1 of 2

Among emergency department patients with substance use disorder, positive urine drug screening and cardiotoxicity, structural cardiac dysfunction was associated with higher in-hospital mortality.

Conclusion · 2 of 2

These findings support early cardiovascular assessment, including electrocardiography, troponin testing and selective echocardiography, in high-risk patients with substance-related toxicity.

Evaluating Cardiotoxicity and Factors Associated with In-Hospital Mortality Among Emergency Department Patients with Substance Use Disorder: An 11-year retrospective study .

Evaluating Cardiotoxicity and Factors Associated with In-Hospital Mortality Among Emergency Department Patients with Substance Use Disorder: An 11-year retrospective study .

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