Development of SCOPE: Social and Clinical Opioid Use Disorder Predisposition Evaluation.

Cohort studyJournal of addiction medicine· Aug 2026

Development of SCOPE: Social and Clinical Opioid Use Disorder Predisposition Evaluation.

Soraya Mehdipour, Carla Marienfeld, Gregory Polston, Rodney A Gabriel

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Addiction MedicineCohort studyDiagnosisQ1IF 2.8

New calculator predicts opioid use disorder risk with strong accuracy

Development of SCOPE: Social and Clinical Opioid Use Disorder Predisposition Evaluation.

Soraya Mehdipour … Rodney A Gabriel

Journal of addiction medicine · Aug 2026 · Q1 in Psychiatry

Purpose

Our study aimed to identify social determinants of health (social determinants of health), demographic, and clinical features associated with opioid use disorder (opioid use disorder) and then to develop a risk calculator, termed Social and Clinical Opioid Use Disorder Predisposition Evaluation (SCOPE), that clinicians may use at the bedside to risk-stratify for opioid use disorder.

Methods

Data from the All of Us Research Program were used.

Results

correctly ranks opioid use disorder risk in most patients; 1.0 would be perfect prediction

78%

Sensitivity

78%

Specificity

More results

There were 624,431 included participants, of whom 2475 (0.39%) had opioid use disorder that was diagnosed >90 days after survey completion.

Defining a cutoff score of 8 as high-risk yielded a sensitivity of 0.79 [95% CI: 0.76-0.83], specificity of 0.76 [95% CI: 0.75-0.76], positive likelihood ratio of 3.35, and negative likelihood ratio of 0.26.

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Conclusion

We identified individual- and social determinants of health-related risk factors for opioid use disorder and developed SCOPE, which may be used as a clinical decision-making aid for personalized risk identification of opioid use disorder.

Development of SCOPE: Social and Clinical Opioid Use Disorder Predisposition Evaluation.

Development of SCOPE: Social and Clinical Opioid Use Disorder Predisposition Evaluation.

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