Plasma CAF22 Predicts Incident Freezing of Gait in Parkinson's Disease: A Prospective Cohort Study.

During follow-up, 55 participants (23.6%) developed incident FOG.

Higher baseline plasma CAF22 was associated with an increased risk of FOG per standard deviation increase (HR 1.4, 95% CI 1.09-1.81).

Baseline CAF22 concentrations were higher in participants with greater motor severity and slower gait speed, but showed weaker associations with global cognitive performance.

Kaplan-Meier analyses demonstrated progressively lower FOG-free survival across increasing CAF22 tertiles (log-rank p = 0.046).