Mapping the Phenotypic Spectrum of Occipital Lobe Epilepsy: A SEEG-Defined Network Classification.
Nearly half of occipital lobe epilepsy seizures followed a dorsal-medial/default mode network-limbic pathway.
Mapping the Phenotypic Spectrum of Occipital Lobe Epilepsy: A SEEG-Defined Network Classification.
Occipital lobe epilepsy (occipital lobe epilepsy) often presents with complex clinical symptoms that extend beyond the occipital lobe, posing significant challenges for diagnosis and lesion localization.
This study aims to systematically characterize the seizure phenotype spectrum of occipital lobe epilepsy using stereo-electroencephalography (stereo-electroencephalography) and elucidates its electrophysiological and anatomical basis.
This single-center, retrospective case series included 19 patients who underwent comprehensive stereo-electroencephalography evaluation.
nearly half followed a dorsal-medial/default mode, limbic pathway, the most common route
Individual patients could exhibit multiple clinical phenotypes across different seizures.
The TPOJ and posterior cingulate/precuneus emerged as key hubs for rapid cross-network propagation and symptom evolution.
Representative cases showed close temporal concordance between clinical semiology and stereo-electroencephalography-defined propagation sequences.
This study proposes a preliminary anatomical-electrophysiological-clinical classification for occipital lobe epilepsy.
Seizure phenotypes in occipital lobe epilepsy were associated with structured, pathway-specific network recruitment rather than nonspecific spread within this single-center cohort.
A phenotype-driven stereo-electroencephalography approach may offer valuable insights into seizure network organization and could inform presurgical evaluation and individualized surgical planning, though these findings require validation in larger, prospective cohorts.