Neonatal Seizures in Tuberous Sclerosis Complex: A Case Series.
Two-thirds of tuberous sclerosis complex infants studied had neonatal seizures
Neonatal Seizures in Tuberous Sclerosis Complex: A Case Series.
Epilepsy affects up to 90% of patients with tuberous sclerosis complex (tuberous sclerosis complex); earlier seizure onset is associated with worse neurocognitive outcomes.
We aimed to determine the rate of neonatal seizures in our cohort of tuberous sclerosis complex patients.
We performed a single-center medical records review of patients with tuberous sclerosis complex who were seen between 2020 and 2025 to identify patients with neonatal seizure onset.
The incidence of neonatal seizures in tuberous sclerosis complex is unknown, although in a recent multicenter trial 23% of infants with tuberous sclerosis complex were excluded prior to randomization because of pre-existing seizures prior to age 4 months, suggesting that neonatal or early infantile seizures may be a common occurrence.
They have not developed epilepsy and have had milder neurodevelopmental impairment.
In conclusion, data from our center suggest that neonatal seizures may be common in tuberous sclerosis complex, especially in high-risk infants with TSC2 with highly epileptogenic lesions.
Of six patients with data from the neonatal period, four (67%) had neonatal seizures. Two had confirmed electrographic seizures in the first week of life, and another two had clinical seizure onset during the neonatal period.
All patients with neonatal seizures had TSC2 and developed drug-resistant epilepsy, and two of four developed infantile spasms despite intensive early medical management, including vigabatrin.
The two patients without neonatal seizures had TSC1 and mosaic TSC2, respectively.