Association between the triglyceride to high-density lipoprotein cholesterol ratio and 90-day post-stroke depression in acute ischemic stroke.

Thirty-three point nine percent of patients developed post-stroke depression.

Restricted cubic splines analysis suggested a potential non-linear relationship, and a two-piecewise logistic regression model identified a candidate inflection point.

However, the wide confidence intervals in the higher exposure range indicate substantial uncertainty, and this finding should be regarded as exploratory.