Effect of Self-Sampling HPV DNA Testing on Cervical Cancer Screening in Singapore's Primary Care: Pragmatic…

Randomized trialAnnals of family medicine· Jul 2026

Effect of Self-Sampling HPV DNA Testing on Cervical Cancer Screening in Singapore's Primary Care: Pragmatic Randomized Controlled Trial.

Xin Rong Ng, Imm Pin Quek, Michelle Jessica Pereira … Sabrina Kay Wye Wong

Prevention & Screening in Primary CareRandomized trialDiagnosisQ1IF 2.5

Offering self-sampling alongside clinician sampling increased high-risk human papillomavirus detection in screening.

Effect of Self-Sampling HPV DNA Testing on Cervical Cancer Screening in Singapore's Primary Care: Pragmatic Randomized Controlled Trial.

Xin Rong Ng … Sabrina Kay Wye Wong

Annals of family medicine · Jul 2026 · Q1 in Family Medicine

Background

In Singapore, cervical cancer screening rates remain suboptimal, with only clinician sampling included in the national screening program.

Methods

This pragmatic, 2-arm randomized controlled trial with Zelen design was conducted across NHG Polyclinics, NHG Health in Singapore.

n = 650 women

Results

self-sampling found high-risk human papillomavirus far more often than clinician sampling alone

Intervention

3.1%

Usual care

0.3%

More results

Among screened participants in the intervention arm, 56.4% chose self-sampling.

Lower educational attainment was associated with lower odds of choosing self-sampling over declining screening.

“

Conclusion · 1 of 3

Offering self-sampling human papillomavirus DNA testing alongside clinician sampling significantly increased screening uptake and high-risk human papillomavirus detection rates.

Conclusion · 2 of 3

However, uptake remained lower among women with less education, highlighting the need for targeted engagement strategies.

Conclusion · 3 of 3

Abstract also available in: عربي (Arabic); Deutsch (German); Español (Spanish); Francais (French); हिन्दी (Hindi); Indonesia (Indonesian); (Chinese); (Japanese); Portugues (Portuguese).

Effect of Self-Sampling HPV DNA Testing on Cervical Cancer Screening in Singapore's Primary Care: Pragmatic Randomized Controlled Trial.

Effect of Self-Sampling HPV DNA Testing on Cervical Cancer Screening in Singapore's Primary Care: Pragmatic Randomized Controlled Trial.

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