Early Corrected QT Interval Changes Following First-dose Long-acting Injectable Antipsychotics: A…

Cohort studyClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology· Aug 2026

Early Corrected QT Interval Changes Following First-dose Long-acting Injectable Antipsychotics: A Retrospective Inpatient Study.

Hayriye Dilek Hamurcu, Esra Kabadayi Sahin, Ersin Hatice Karslıoğlu … Ali Çayköylü

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Hospital MedicineCohort studyClinical practiceQ1IF 3.5

Early QT increases after first long-acting injectable antipsychotic dose stayed under 10 ms.

Early Corrected QT Interval Changes Following First-dose Long-acting Injectable Antipsychotics: A Retrospective Inpatient Study.

Hayriye Dilek Hamurcu … Ali Çayköylü

Clinical psychopharmacology and neuroscience · Aug 2026

Purpose

Long-acting injectable (long-acting injectable) antipsychotics improve adherence and reduce relapse, yet short-term cardiac effects during the initial dosing window remain insufficiently characterized.

Methods

We conducted a retrospective chart review of psychiatric inpatients who received their first long-acting injectable antipsychotic during admission.

Results

no clinically meaningful QT rise after first long-acting injectable dose

418.7ms

Baseline

421ms

Post-injection

More results

Sixty-three patients had paired electrocardiograms recordings.

Baseline QT values were comparable across subgroups.

In regression analysis (R 2 = 0.565), baseline QT was the only independent predictor of post-injection QT (β = 0.687, p < 0.001).

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Conclusion · 1 of 2

Early QT changes after long-acting injectable initiation were small and not clinically meaningful.

Conclusion · 2 of 2

Post-injection QT was mainly determined by baseline QT, supporting guideline-concordant electrocardiograms monitoring without routine intensified cardiac surveillance in low-risk patients.

Early Corrected QT Interval Changes Following First-dose Long-acting Injectable Antipsychotics: A Retrospective Inpatient Study.

Early Corrected QT Interval Changes Following First-dose Long-acting Injectable Antipsychotics: A Retrospective Inpatient Study.

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