Multimorbidity patterns among fragility fracture patients aged 50 + years in China and the US.

Cohort studyOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA· Jun 2026

Multimorbidity patterns among fragility fracture patients aged 50 + years in China and the US.

Qi Meng, Yi Wang, Linghua Yang … Shuman Yang

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Multimorbidity & PolypharmacyCohort studyQ1IF 4.7

Osteoporosis, not hyperlipidemia, is the top comorbidity in US women with fragility fractures.

Multimorbidity patterns among fragility fracture patients aged 50 + years in China and the US.

Qi Meng … Shuman Yang

Osteoporosis international · Jun 2026 · Q1 in General Medicine

Purpose

To examine the multimorbidity patterns among fragility fracture patients aged 50 + years in China and the US.

Methods

We extracted inpatient electronic medical records at the First Affiliated Hospital of Jinzhou Medical University, China between 2018 and 2023, and data from the National Health and Nutrition Examination Survey (National Health and Nutrition Examination Survey) 1999-2020.

n = 2086 Chinese fracture patients,

78.3%

Results

78.3%

osteoporosis, not hyperlipidemia, was the leading comorbidity in women with fractures

n = 2086 Chinese fracture patients,

More results

The most prevalent comorbidity among Chinese fracture patients was hyperlipidemia (male: 63.3%; female: 65.2%).

The most prevalent disease pair was osteoporosis and hyperlipidemia among US fracture patients (male: 40.8%; female: 61.4%), and hypertension and hyperlipidemia among Chinese fracture patients (male: 26.6%; female: 29.4%).

“

Conclusion · 1 of 2

Except among female fracture patients in the US, hyperlipidemia was the most prevalent comorbidity among Chinese and US fragility fracture patients.

Conclusion · 2 of 2

US fracture patients demonstrated a similar complex comorbidity network to non-fracture individuals.

Multimorbidity patterns among fragility fracture patients aged 50 + years in China and the US.

Multimorbidity patterns among fragility fracture patients aged 50 + years in China and the US.

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