Outcomes of patients with trisomy 13 and 18 in a center with a dedicated perinatal palliative care program.

Cohort studyJournal of perinatology : official journal of the California Perinatal Association· Jul 2026

Outcomes of patients with trisomy 13 and 18 in a center with a dedicated perinatal palliative care program.

Sinead Brady, Bryn McNamee-Tweed, Yuan S Zhang … Elvira Parravicini

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Palliative & End-of-LifeCohort studyClinical practiceQ1IF 2.5

Most counseled families with trisomy 13 or 18 chose comfort care

Outcomes of patients with trisomy 13 and 18 in a center with a dedicated perinatal palliative care program.

Sinead Brady … Elvira Parravicini

Journal of perinatology · Jul 2026

Background

The objective of this study is to assess outcomes of pregnancies complicated by trisomy 13(T13) or trisomy 18(T18) and infants with T13 and T18, who were managed in a center with a perinatal palliative care program.

Methods

This is a single center retrospective cohort study of neonates with T13 or T18 and pregnancies complicated by T13 or T18 in which families opted to continue the pregnancy, that were followed at Columbia University Irving Medical Center(Columbia University Irving Medical Center) between 2008 and 2024.

n = 109 pregnancies

69.9%

Results

69.9%

most families offered comfort care after diagnosis chose it over intervention

n = 109 pregnancies

More results

There were 109 pregnancies that resulted in 68 liveborn infants.

There was no trend toward more intervention over a span of 17 years.

“

Conclusion

Differing from other institutions, the lack of trend toward more intervention in patients with T13 and T18 at Columbia University Irving Medical Center, may be due to the consistency of consultation practice by the Neonatal Comfort Care Program.

Outcomes of patients with trisomy 13 and 18 in a center with a dedicated perinatal palliative care program.

Outcomes of patients with trisomy 13 and 18 in a center with a dedicated perinatal palliative care program.

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