Exploring the Association of Polypharmacy and Depressive Symptoms with Sarcopenia in Older Adults.

Cross-sectionalJournal of clinical medicine· Jul 2026

Exploring the Association of Polypharmacy and Depressive Symptoms with Sarcopenia in Older Adults.

Bader A Alqahtani, Aqeel M Alenazi

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GeriatricsCross-sectionalClinical practiceQ2IF 3.5

Polypharmacy far more common in older adults with sarcopenia than without.

Exploring the Association of Polypharmacy and Depressive Symptoms with Sarcopenia in Older Adults.

Bader A Alqahtani, Aqeel M Alenazi

Journal of clinical medicine · Jul 2026 · Q2 in General Medicine

Purpose

This study aimed to investigate the prevalence of and risk factors for sarcopenia in community-dwelling older adults.

Methods

This cross-sectional study was conducted in Riyadh between February and May 2024.

n = 182 participants

Results

more than 3x as many took 5+ daily medications

Polypharmacy (sarcopen

55%

Polypharmacy (non-sarc

16%

More results

Approximately 11% ( n = 20) of participants were identified as having sarcopenia based on the AWGS criteria.

“

Conclusion · 1 of 3

This study identified an increased prevalence of sarcopenia among the geriatric population in the Kingdom of Saudi Arabia using the AWGS criteria.

Conclusion · 2 of 3

The associated risk factors for sarcopenia included older age, polypharmacy, and depressive symptoms.

Conclusion · 3 of 3

These associations underscore the complex systemic interplay between physical health, mental well-being, and therapeutic management in geriatric care.

Exploring the Association of Polypharmacy and Depressive Symptoms with Sarcopenia in Older Adults.

Exploring the Association of Polypharmacy and Depressive Symptoms with Sarcopenia in Older Adults.

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