Hypertension and ovarian cancer risk: a meta-analysis of observational studies.

Case-controlArchives of medical science : AMS· 2026

Hypertension and ovarian cancer risk: a meta-analysis of observational studies.

Agnieszka Drab, Krystian Wdowiak, Wiesław Kanadys … Urszula Religioni

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OncologyCase-controlQ2IF 2.8

Hypertension is associated with higher risk of ovarian cancer

Hypertension and ovarian cancer risk: a meta-analysis of observational studies.

Agnieszka Drab … Urszula Religioni

Archives of medical science · 2026 · Q2 in General Medicine

Background

Ovarian cancer is the eighth most common cancer among women and an important cause of cancer-related mortality, particularly in high-income countries.

Methods

We performed a literature search of all of the observational studies published as original articles from inception to July 2024, and we searched the following electronic databases: PubMed, Embase, and Cochrane Library.

n = 2,497,898 women

Results

Women with hypertension had a modestly higher relative risk of ovarian cancer.

RR 1.10 (95% CI 1.02 to 1.23)

null 1

1.02

1.23

CI excludes the null - significant

More results

The meta-analysis included a total of 2,497,898 women.

Subgroup analysis showed that parity may significantly reduce the ovarian cancer risk, which was higher among women who had never given birth (RR = 1.43, p < 0.0025), while a body mass index (BMI) > 25 kg/m 2 increased the risk of ovarian cancer (RR = 1.12, p < 0.0001).

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Conclusion · 1 of 2

The findings of this comprehensive review and meta-analysis indicate that hypertension is associated with higher overall risk of ovarian cancer.

Conclusion · 2 of 2

While the present data provide novel evidence, further prospective studies are needed to elucidate the association between hypertension and ovarian cancer risk.

Hypertension and ovarian cancer risk: a meta-analysis of observational studies.

Hypertension and ovarian cancer risk: a meta-analysis of observational studies.

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