Prognostic value of international normalized ratio in cancer patients with sepsis: A retrospective cohort study and secondary analysis.
Higher admission international normalized ratio independently linked to 72-hour mortality in septic cancer patients
Prognostic value of international normalized ratio in cancer patients with sepsis: A retrospective cohort study and secondary analysis.
Sepsis is a life-threatening condition with high mortality, particularly in vulnerable populations such as cancer patients.
This study aimed to determine the prognostic value and optimal cutoff point of international normalized ratio for predicting 72-hour mortality in this specific patient cohort.
This retrospective cohort study was a secondary analysis of data from a publicly available dataset in the Dryad Digital Repository, which included 225 patients with sepsis (122 of whom had cancer).
higher international normalized ratio on admission raised the odds of death within 72 hours
A higher admission international normalized ratio was significantly associated with 72-hour mortality in cancer patients with sepsis.
The receiver operating characteristic analysis for international normalized ratio yielded an area under the curve of 0.7509 (95% confidence interval = 0.6385-0.8632).
The optimal cutoff value was identified as 1.6, which provided a sensitivity of 58.33% and a specificity of 80.61%.
Admission international normalized ratio is an independent predictor of 72-hour mortality in cancer patients with sepsis.
With an optimal cutoff of 1.6, this readily available biomarker can serve as a valuable and inexpensive tool for early risk stratification in the emergency care of this high-risk population.