Endoscopic Sleeve Gastroplasty for Type 2 Diabetes: A Systematic Review and Meta-Analysis Focusing on…

Cohort studyDiabetes, metabolic syndrome and obesity : targets and therapy· 2026

Endoscopic Sleeve Gastroplasty for Type 2 Diabetes: A Systematic Review and Meta-Analysis Focusing on Diabetes Remission, Glycemic Control and Body Weight Loss.

Xiao Qiu, Shanju Yu

EndocrinologyCohort studyTreatmentQ2IF 3.4

Most patients achieved type 2 diabetes remission after endoscopic sleeve gastroplasty

Endoscopic Sleeve Gastroplasty for Type 2 Diabetes: A Systematic Review and Meta-Analysis Focusing on Diabetes Remission, Glycemic Control and Body Weight Loss.

Xiao Qiu, Shanju Yu

Diabetes, metabolic syndrome and obesity · 2026 · Q2 in Internal Medicine

Purpose

To systematically evaluate metabolic outcomes of endoscopic sleeve gastroplasty (endoscopic sleeve gastroplasty) in patients with type 2 diabetes mellitus (T2DM), focusing on T2DM remission, T2DM improvement, glycated hemoglobin (HbA1c), and percentage of total body weight loss (%TBWL).

Methods

PubMed, Embase, Web of Science, Cochrane Library, and MEDLINE were searched for cohort studies through December 2025.

n = 519 patients

Results

nearly two-thirds of patients went into diabetes remission after endoscopic sleeve gastroplasty

effect size 1.89 (95% CI 1.71 to 2.06)

null 0

1.71

2.06

CI excludes the null - significant

More results

The pooled mean difference for HbA1c was 0.60% (95% CI [0.23, 0.97], P = 0.001), and for %TBWL was 10.89% (95% CI [6.24, 15.54], P < 0.001).

Subgroup analyses showed %TBWL of 12.84% (95% CI [10.86, 14.82]) at 12 months and 14.00% (95% CI [11.76, 16.24]) at 3 years.

More results

Patients with baseline HbA1c ≥ 7.0% had greater HbA1c reduction than those with baseline HbA1c < 7.0% (-1.00% vs -0.50%).

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Conclusion · 1 of 2

Endoscopic sleeve gastroplasty improves T2DM remission, glycemic control, and weight loss, with effects sustained up to 3 years. Patients with higher baseline glycemic levels derived greater benefits.

Conclusion · 2 of 2

endoscopic sleeve gastroplasty may represent an effective minimally invasive treatment option for T2DM, although further randomized trials are needed to confirm this finding.

Endoscopic Sleeve Gastroplasty for Type 2 Diabetes: A Systematic Review and Meta-Analysis Focusing on Diabetes Remission, Glycemic Control and Body Weight Loss.

Endoscopic Sleeve Gastroplasty for Type 2 Diabetes: A Systematic Review and Meta-Analysis Focusing on Diabetes Remission, Glycemic Control and Body Weight Loss.

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