The Safety of Single Aminoglycoside Dose in Emergency Departments (SAD-ED) Among Patients With and Without…

Cohort studyEmergency medicine Australasia : EMA· Aug 2026

The Safety of Single Aminoglycoside Dose in Emergency Departments (SAD-ED) Among Patients With and Without Chronic Kidney Disease: A Retrospective Cohort Study.

Grace Lau, Charles Xin, Roy Kadira … Iouri Banakh

NephrologyCohort studyClinical practice

Chronic kidney disease was associated with higher odds of acute kidney injury after aminoglycosides

The Safety of Single Aminoglycoside Dose in Emergency Departments (SAD-ED) Among Patients With and Without Chronic Kidney Disease: A Retrospective Cohort Study.

Grace Lau … Iouri Banakh

Emergency medicine Australasia · Aug 2026

Purpose

The aim of this study was to determine the safety of single-dose aminoglycosides (single-dose aminoglycosides) in Emergency Departments (Emergency Departments) in patients with and without chronic kidney disease.

Methods

A retrospective cohort study was performed in four tertiary hospitals within a multi-site Australian metropolitan hospital network.

n = 660 patients

Results

chronic kidney disease nearly triples the odds of AKI after aminoglycosides

OR 2.88 (95% CI 1.76 to 4.71)

null 1

1.76

4.71

CI excludes the null - significant

More results

Patients received gentamicin (74.1%), tobramycin (25.6%), or amikacin (0.3%).

“

Conclusion · 1 of 2

Patients with chronic kidney disease who received single-dose aminoglycosides were more likely to have AKI compared to patients without chronic kidney disease.

Conclusion · 2 of 2

Clinicians should carefully balance the risks and benefits of empiric aminoglycosides in patients with chronic kidney disease and consider such therapy only if no other suitable alternatives exist.

The Safety of Single Aminoglycoside Dose in Emergency Departments (SAD-ED) Among Patients With and Without Chronic Kidney Disease: A Retrospective Cohort Study.

The Safety of Single Aminoglycoside Dose in Emergency Departments (SAD-ED) Among Patients With and Without Chronic Kidney Disease: A Retrospective Cohort Study.

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