Prevention of new-onset chronic kidney disease with renin-angiotensin system blockers in type 2 diabetes with preserved kidney function.

However, whether renin-angiotensin system blockade can prevent new-onset chronic kidney disease in patients with type 2 diabetes and hypertension who maintain preserved kidney function remains unclear.

Beginning with 316,693 individuals with type 2 diabetes and newly diagnosed hypertension, we retained 3,316 angiotensin-converting enzyme inhibitors/angiotensin receptor blockers users and 1,409 nonusers after generalized boosted model weighting to equalize baseline characteristics.