Omega-3-rich fish oil lipid emulsions prevent sepsis-driven mesenteric hypoperfusion and multiorgan injury in a murine model.

Lipopolysaccharide injection significantly reduced mesenteric blood flow when compared to saline controls (3.02 ± 0.10 mL/min vs 1.44 ± 0.10 mL/min, p < 0.05).

None of the tested lipid emulsions prevented lipopolysaccharide-induced increases in liver and spleen weights.

Fish oil reduced liver damage in septic mice, whereas specific dosages of olive and soybean oils caused significant histopathological liver and spleen damage even in the control animals.

Furthermore, soybean and olive oil also significantly increased serum oxidative stress in the healthy control mice (2.55 ± 0.06 vs 4.93 ± 0.38 and 4.28 ± 0.12, p <0.05).