Long non-coding RNA SNHG6 promotes the proliferation of PASMCs cells through the miR-429/DUSP1 axis during early/subacute vascular responses to pulmonary embolism.

The CCK-8 assay evaluated cell proliferation, while the ELISA and western blot assays measured the relevant protein levels.

SNHG6 was significantly overexpressed in both serum samples from acute pulmonary embolism patients and lung tissues from model rats.

Mechanistic studies revealed that SNHG6 targeted and regulated miR-429, which in turn targeted DUSP1.

Animal experiments performed at a 7‑day subacute endpoint demonstrated that SNHG6 perturbation was associated with altered mean pulmonary artery pressure and early proliferative molecular markers during the early phase following embolic challenge.