Diagnostic and Prognostic Accuracy of Cardiorespiratory Fitness for Detecting Cardiovascular Risk and Mitochondrial Disorders: An Overview of Systematic Reviews with Meta-Analyses.

Cardiorespiratory fitness detects cardiovascular disease and mitochondrial disorders and predicts cardiovascular events among adults with chronic conditions and detects cardiovascular risk among apparently healthy children; however, the certainty of evidence ranged from very low to high certainty due to methodological limitations.

Further research is needed to generate high-quality diagnostic evidence for cardiorespiratory fitness across diverse health outcomes and age groups in the general population.