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New research · Internal Medicine
Clinical research in cardiology : official journal of the German Cardiac Society · 3h
Cohort studyClinical research in cardiology : official journal of the German Cardiac Society · 2026

Aspirated thrombus weight and volume are not associated with improvements in hemodynamics after large-bore mechanical thrombectomy in pulmonary embolism.

Felix Götzinger, Lucas Lauder, Patricia Perez Navarro … Felix Mahfoud
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Internal MedicineCohort study

Amount of thrombus removed did not correlate with pulmonary artery pressure improvement.

Aspirated thrombus weight and volume are not associated with improvements in hemodynamics after large-bore mechanical thrombectomy in pulmonary embolism.

Felix Götzinger … Felix Mahfoud
Clinical research in cardiology : official journal of the German Cardiac Society · 2026
Background

Large-bore mechanical thrombectomy (large-bore mechanical thrombectomy) is a catheter-directed therapy for acute pulmonary embolism (pulmonary embolism).

Purpose

The aim was to evaluate the impact of aspirated thrombus weight and volume on outcomes after large-bore mechanical thrombectomy.

Methods

This prospective, open-label, single-arm, single-center registry study included 48 patients undergoing large-bore mechanical thrombectomy using the FlowTriever system (Inari Medical/Stryker, Irvine, CA, USA).

n = 48 patients
ρ = 0.10
Results
ρ = 0.10
clot amount removed didn't predict pressure improvement
n = 48 patients
More results

Thrombus material was available in 48 patients (31% women), of which 41 presented with intermediate-risk and 7 with high-risk pulmonary embolism.

More results

Large-bore mechanical thrombectomy resulted in significant reductions in systolic pulmonary artery pressures (sPAP) intraprocedurally (- 12.8 ± 8.3 mmHg, p < 0.001), with a further invasively measured decrease through 3 months (- 9.6 ± 10.6 mmHg, p < 0.001).

“
Conclusion

Aspirated thrombus weight and volume were not associated with improvements after large-bore mechanical thrombectomy, suggesting that, beyond mechanical obstruction, additional mechanisms potentially including paracrine and endocrine effects of thrombus material may contribute to acute and chronic pulmonary embolism-related cardiopulmonary dysfunction.

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