Development and internal-external validation of a nomogram model for lower extremity deep vein thrombosis in…

Cohort studyInternational journal of medical informatics· Jul 2026

Development and internal-external validation of a nomogram model for lower extremity deep vein thrombosis in patients after ruptured intracranial aneurysm surgery based on dynamic D-dimer trajectory.

Jiansong Yu, Ting Guo, Wei Hu … Yongpo Jiang

Venous ThromboembolismCohort studyPrognosisQ1IF 6.2

Nomogram using D-dimer trajectory predicted deep vein thrombosis after aneurysm surgery in external validation

Development and internal-external validation of a nomogram model for lower extremity deep vein thrombosis in patients after ruptured intracranial aneurysm surgery based on dynamic D-dimer trajectory.

Jiansong Yu … Yongpo Jiang

International journal of medical informatics · Jul 2026

Purpose

This study aimed to develop and validate a nomogram model for predicting lower extremity deep venous thrombosis (lower extremity deep venous thrombosis) after ruptured intracranial aneurysm (ruptured intracranial aneurysm) surgery based on dynamic D-dimer trajectory, to support accurate identification of high-risk populations and individualized thrombosis prevention in clinical practice.

Methods

Were split into training and test sets at an 8:2 ratio; an independent external validation set included patients from another hospital.

n = 294,

Results

correctly separates future clot cases from those without most of the time

Training set

0.76AUC

Test set

0.81AUC

External validation

0.75AUC

More results

Four D-dimer trajectory subgroups were identified by Gaussian Mixture Model.

LASSO regression screened age, surgical type, GCS score and D-dimer trajectory as key predictors.

“

Conclusion

This validated nomogram integrating four core factors can accurately predict postoperative lower extremity deep venous thrombosis risk in ruptured intracranial aneurysm patients.

Development and internal-external validation of a nomogram model for lower extremity deep vein thrombosis in patients after ruptured intracranial aneurysm surgery based on dynamic D-dimer trajectory.

Development and internal-external validation of a nomogram model for lower extremity deep vein thrombosis in patients after ruptured intracranial aneurysm surgery based on dynamic D-dimer trajectory.

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