ScholarDeck

Case reportFrontiers in fungal biology · 2026

Metagenomic next-generation sequencing in diagnosing rhino-orbital-cerebral mucormycosis presenting as cerebral Infarction: a case series and diagnostic analysis of seven patients.

Fei Yang, Chenglin Yang, Hongqiang Li … Shuguang Zhang

OphthalmologyCase report

Rhino-orbital-cerebral mucormycosis presenting as cerebral infarction had very high mortality despite treatment.

Metagenomic next-generation sequencing in diagnosing rhino-orbital-cerebral mucormycosis presenting as cerebral Infarction: a case series and diagnostic analysis of seven patients.

Fei Yang … Shuguang Zhang

Frontiers in fungal biology · 2026

Background

Rhino-orbital-cerebral mucormycosis (rhino-orbital-cerebral mucormycosis) is a rare, rapidly progressive, and fatal invasive fungal infection.

Results

85.7%

6 of 7 patients had facial swelling despite treatment, a common warning sign

More results

All seven patients had diabetes mellitus, with six concurrently presenting with ketoacidosis.

Universal clinical features included fever and a fixed, dilated pupil.

Cerebral infarction was confirmed by head magnetic resonance imaging (magnetic resonance imaging) in all individuals.

More results

Six patients received treatment with amphotericin B cholesteryl sulfate complex, and two of these also underwent surgical debridement.

“

Conclusion · 1 of 3

Rhino-orbital-cerebral mucormycosis should be highly suspected in diabetic patients presenting with acute cerebral infarction accompanied by fever and facial or ocular symptoms.

Conclusion · 2 of 3

mNGS enables rapid and early etiological diagnosis of rhino-orbital-cerebral mucormycosis, which is crucial for improving outcomes.

Conclusion · 3 of 3

Earlier diagnosis, combined antifungal therapy, and surgical intervention may be associated with better prognosis.

Post

Metagenomic next-generation sequencing in diagnosing rhino-orbital-cerebral mucormycosis presenting as cerebral Infarction: a case series and diagnostic analysis of seven patients.

Rhino-orbital-cerebral mucormycosis presenting as cerebral infarction had very high mortality despite treatment.

Related papers