Efficacy of Topical Chemotherapy in Ocular Adnexal Sebaceous Carcinoma.

Patient inclusion criteria included: (1) biopsy-proven diagnosis of OaSC, (2) intraepithelial pagetoid involvement confirmed by conjunctival map biopsy, (3) implementation of topical chemotherapy for tumor control, and (4) repeat conjunctival map biopsy following cessation of topical chemotherapy.

Topical chemotherapy agents were utilized via monotherapy or in combination and included mitomycin C (mitomycin C) 0.02% or 0.04% (8 cases), 5-fluorouracil 1% (3 cases), and interferon alpha-2a 1 million units/ml (2 cases).

Resolution of pagetoid disease was achieved in 2 patients (2/10, 20%) with mitomycin C monotherapy.