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Cohort studyOphthalmic plastic and reconstructive surgery · 2026

Efficacy of Topical Chemotherapy in Ocular Adnexal Sebaceous Carcinoma.

Andrew J Rong, Matthew Camacho, Sander R Dubovy … Nathan W Blessing

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OphthalmologyCohort study

Topical chemotherapy failed to control intraepithelial spread in most sebaceous carcinoma cases.

Efficacy of Topical Chemotherapy in Ocular Adnexal Sebaceous Carcinoma.

Andrew J Rong … Nathan W Blessing

Ophthalmic plastic and reconstructive surgery · 2026

Purpose

This study aimed to report clinical outcomes of topical chemotherapy for ocular adnexal sebaceous carcinoma (OaSC) with intraepithelial spread.

Methods

We reviewed 120 patients with OaSC and 10 patients met the inclusion criteria (n = 10).

n = 120 patients

Results

chemo failed to clear early spreading skin cancer cells in most patients

80%

Inadequate control

20%

Resolution of pagetoid

More results

Patient inclusion criteria included: (1) biopsy-proven diagnosis of OaSC, (2) intraepithelial pagetoid involvement confirmed by conjunctival map biopsy, (3) implementation of topical chemotherapy for tumor control, and (4) repeat conjunctival map biopsy following cessation of topical chemotherapy.

More results

Topical chemotherapy agents were utilized via monotherapy or in combination and included mitomycin C (mitomycin C) 0.02% or 0.04% (8 cases), 5-fluorouracil 1% (3 cases), and interferon alpha-2a 1 million units/ml (2 cases).

Resolution of pagetoid disease was achieved in 2 patients (2/10, 20%) with mitomycin C monotherapy.

“

Conclusion

Topical mitomycin C may be used in the neoadjuvant setting for OaSC with pagetoid spread; however, additional studies are needed to determine the optimal dosing and treatment duration to minimize adverse effects and reduce ocular surface comorbidity.

Post

Efficacy of Topical Chemotherapy in Ocular Adnexal Sebaceous Carcinoma.

Topical chemotherapy failed to control intraepithelial spread in most sebaceous carcinoma cases.

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