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New research · Ophthalmology
Noro psikiyatri arsivi · 12h
StudyNoro psikiyatri arsivi · 2026

Aquaporin-1 Antibodies in Autoimmune Inflammatory Demyelinating Disorders with Predominant Optic Nerve & Spinal Cord Involvement.

Erdem Tüzün, Eleni Karachaliou, Maria Pechlivanidou … John Tzartos
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OphthalmologyStudy

AQP1 antibodies found in 11% of patients with optic neuritis or myelitis

Aquaporin-1 Antibodies in Autoimmune Inflammatory Demyelinating Disorders with Predominant Optic Nerve & Spinal Cord Involvement.

Erdem Tüzün … John Tzartos
Noro psikiyatri arsivi · 2026
Background

Antibodies to the extracellular domain of the astrocytic aquaporin-1 (AQP-1) have been reported in patients with neuromyelitis optica spectrum disorder (neuromyelitis optica spectrum disorder) and a few multiple sclerosis (multiple sclerosis) patients with predominant spinal cord involvement.

Methods

Sera from patients with neuromyelitis optica spectrum disorder (n=30), recurrent inflammatory optic neuropathy (recurrent inflammatory optic neuropathy) (n=15), relapsing remitting multiple sclerosis (relapsing remitting MS) (n=69), of which 10 had optic neuritis and/or short myelitis, and healthy controls (n=36) were screened for the presence of AQP1-Abs by ELISA and for antibodies against aquaporin-4 (AQP4-Abs) and myelin oligodendrocyte glycoprotein (myelin oligodendrocyte glycoprotein)-Abs by cell-based assays.

n = 30
Results

blood test for this antibody was positive in only a small share of patients

NMOSD
6.7%
RION
13.3%
RRMS with optic neurit
20%
More results

None of the relapsing remitting MS patients without optic neuritis and/or short myelitis and none of the healthy controls had AQP1-Abs.

The two AQP1-Abs-positive relapsing remitting MS patients, who fulfilled Barkhof criteria by virtue of MRI lesion distribution, had experienced ≥4 short myelitis and/or optic neuritis attacks.

“
Conclusion

AQP1-Abs are occasionally detected in autoimmune inflammatory demyelinating central nervous system disorders highlighting optic nerve and spinal cord involvement.

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