Aquaporin-1 Antibodies in Autoimmune Inflammatory Demyelinating Disorders with Predominant Optic Nerve & Spinal Cord Involvement.

Sera from patients with neuromyelitis optica spectrum disorder (n=30), recurrent inflammatory optic neuropathy (recurrent inflammatory optic neuropathy) (n=15), relapsing remitting multiple sclerosis (relapsing remitting MS) (n=69), of which 10 had optic neuritis and/or short myelitis, and healthy controls (n=36) were screened for the presence of AQP1-Abs by ELISA and for antibodies against aquaporin-4 (AQP4-Abs) and myelin oligodendrocyte glycoprotein (myelin oligodendrocyte glycoprotein)-Abs by cell-based assays.