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Cohort studyThe Journal of craniofacial surgery · 2026

Neuro-Ophthalmologic and Vestibular Outcomes in Patients With Unilateral Coronal Craniosynostosis.

Victoria Kong, Omar Allam, Andrew Salib … Michael Alperovich

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OphthalmologyCohort study

Unilateral coronal craniosynostosis is associated with a higher risk of balance disorders

Neuro-Ophthalmologic and Vestibular Outcomes in Patients With Unilateral Coronal Craniosynostosis.

Victoria Kong … Michael Alperovich

The Journal of craniofacial surgery · 2026

Background

Unilateral coronal craniosynostosis (UCS) leads to significant craniofacial asymmetry and is associated with ocular anomalies.

Methods

With operatively repaired UCS (n=637) were matched 1:2 to control pediatric patients without craniosynostosis, based on age, sex, race, and ethnicity.

n = 637

Results

vestibular checks found more balance disorders in coronal craniosynostosis children

7.5%

UCS

2.1%

Control

More results

Of 637 UCS patients (median age at repair: 8.3 mo), significant elevations in neuro-ophthalmologic and vestibular comorbidities were observed.

UCS patients exhibited higher rates of strabismus (29.7% versus 1.5%; P<0.001) and amblyopia (22.4% versus 0.6%; P<0.001).

More results

Chiari malformation was also more prevalent in the UCS cohort (0.8% versus 0%, P=0.007).

Time-to-event analysis confirmed higher cumulative risks for strabismus, amblyopia, and balance disorders in the UCS group (P<0.001).

“

Conclusion · 1 of 2

Children with unilateral coronal craniosynostosis have an elevated risk of neuro-ophthalmologic and vestibular impairments, including a novel 5.4% risk difference in balance disorders.

Conclusion · 2 of 2

These findings support the need for comprehensive and early ophthalmologic and vestibular screening.

Post

Neuro-Ophthalmologic and Vestibular Outcomes in Patients With Unilateral Coronal Craniosynostosis.

Unilateral coronal craniosynostosis is associated with a higher risk of balance disorders

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