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New research · Ophthalmology
Korean journal of ophthalmology : KJO · 13h
Cohort studyKorean journal of ophthalmology : KJO · 2026

Comparison of Clinical Outcomes of Intravitreal 0.625% Povidone-Iodine versus Antibiotic Injection for Postoperative Endophthalmitis.

Su Min Lee, Seungwoo Lee, Woo Jung Chae, Han Sang Park
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OphthalmologyCohort study

Severe visual impairment after treatment far less common with intravitreal povidone-iodine than antibiotics

Comparison of Clinical Outcomes of Intravitreal 0.625% Povidone-Iodine versus Antibiotic Injection for Postoperative Endophthalmitis.

Su Min Lee … Han Sang Park
Korean journal of ophthalmology : KJO · 2026
Background

Postoperative endophthalmitis is a sight-threatening intraocular infection requiring prompt treatment.

Purpose

This study aimed to compare the clinical outcomes of intravitreal 0.625% povidone-iodine (povidone-iodine) injection with intravitreal antibiotic injection for the treatment of postoperative endophthalmitis.

Methods

A retrospective review of 40 eyes diagnosed with postoperative endophthalmitis was conducted.

n = 40 eyes
Results

chance of severe vision loss after treatment was much lower with povidone-iodine

25%
PI group
62.5%
Antibiotic group
More results

Group 1 (24 eyes) showed significant improvements in BCVA posttreatment (mean, 1.04 ± 0.95 logMAR; p < 0.001) compared to group 2 (16 eyes; mean, 1.26 ± 0.99 logMAR; p = 0.092).

The mean duration of hypopyon was shorter in group 1 (2.6 ± 2.2 days) compared to group 2 (6.4 ± 7.3 days, p = 0.048).

More results

Fewer intravitreal injections (p = 0.002) and pars plana vitrectomy (p = 0.002) were required in group 1.

“
Conclusion · 1 of 2

Intravitreal 0.625% povidone-iodine injection was associated with fewer intravitreal injections, shorter hypopyon duration, and more favorable visual outcome-related measures, including significant visual improvement from baseline and a lower frequency of severe visual impairment, compared with intravitreal antibiotic treatment.

Conclusion · 2 of 2

These findings suggest that povidone-iodine may be considered a safe and effective initial treatment option for postoperative endophthalmitis. Further prospective studies are needed to validate these results.

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