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New research · Ophthalmology
Cureus · 13h
Case reportCureus · 2026

Primary Central Nervous System Lymphoma as a Masquerade of Uveitis: A Case Report of Ocular Involvement.

Sue-Zian Goh, Kwang-Sheng Ng, Wan-Hazabbah Wan Hitam … Mohammad Hudzaifah Nordin
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OphthalmologyCase report

Neuro-sparing chemotherapy and rituximab restored vision to 6/9 in central nervous system lymphoma

Primary Central Nervous System Lymphoma as a Masquerade of Uveitis: A Case Report of Ocular Involvement.

Sue-Zian Goh … Mohammad Hudzaifah Nordin
Cureus · 2026
Background

Primary central nervous system lymphoma (primary central nervous system lymphoma) often presents with ocular involvement that mimics benign inflammatory conditions, frequently delaying diagnosis.

Results
6/9
vision improved to a normal reading level after treatment
More results

We report a case of a 41-year-old healthy woman presenting with diminished vision and floaters.

Examination revealed panuveitis with characteristic hypopigmented retinal lesions exhibiting a 'leopard-skin' pattern.

More results

Despite the absence of systemic symptoms and a vitreous sample of low cellularity, diagnostic pars plana vitrectomy confirmed large B-cell lymphoma via immunophenotyping (CD20, CD79a and PAX5).

Subsequent magnetic resonance imaging (magnetic resonance imaging) demonstrated a parieto-occipital brain mass.

“
Conclusion

This case underscores the importance of recognising pathognomonic retinal signs and employing molecular immunophenotyping to enable timely, life-saving, neuro-sparing therapy.

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