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New research · Ophthalmology
Experimental eye research · 10h
ObservationalExperimental eye research · 2026

p120-catenin downregulation selectively modulates inflammatory susceptibility in eyelid specimens of rosacea.

Annette Y Kaminaka, Ramon Bossardi-Ramos, Alejandro P Adam, Edward J Wladis
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OphthalmologyObservational

Nuclear p120-catenin localization was reduced 16% in rosacea eyelid tissue versus controls.

p120-catenin downregulation selectively modulates inflammatory susceptibility in eyelid specimens of rosacea.

Annette Y Kaminaka … Edward J Wladis
Experimental eye research · 2026
Background

Previous investigations have implicated the p120-catenin (p120) system in the regulation of cutaneous inflammation.

Methods

This prospective observational study was performed to evaluate adherens junction and tight junction protein expression in eyelid specimens of rosacea.

n = 16 patients
16%
Results
16%
eyelid tissue in rosacea patients showed less of this key repair-signaling protein inside cell nuclei
n = 16 patients
More results

Lysates were made from elective repair of involutional ectropion tissue.

Western blotting expression was determined by band densitometry.

On immunohistochemical, there was no significant difference in junctional staining intensity scores between rosacea and control patients.

More results

These results suggest that nuclear p120 is downregulated in eyelid specimens of rosacea, while other key junctional proteins appear unaffected.

“
Conclusion

While these findings are consistent with p120's role in inflammatory signaling with previously implicated proteins in rosacea and suggest that this downregulation facilitates the pathogenesis of rosacea through signal transduction effects without overt disruption of epithelial junction integrity, additional study may clarify the role of p120 in its pathogenesis.

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