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Cohort studyOcular immunology and inflammation · 2026

Incidence and Prevalence of Depression, Anxiety, and Suicidal Ideation in Patients with Uveitis and Scleritis in the TriNetX Database.

Rajit Agarwal, Daniel Lee, Israel Mendez Bermudez, Meghan K Berkenstock

OphthalmologyCohort study

Uveitis was associated with a 78% higher risk of depression

Incidence and Prevalence of Depression, Anxiety, and Suicidal Ideation in Patients with Uveitis and Scleritis in the TriNetX Database.

Rajit Agarwal … Meghan K Berkenstock

Ocular immunology and inflammation · 2026

Purpose

To evaluate the incidence and prevalence of depression, anxiety, and suicidal ideation (suicidal ideation) in patients with uveitis and scleritis in the TriNetX US Collaborative Network.

Methods

A retrospective study was conducted using ICD-10 codes to identify patients with uveitis and scleritis who were then diagnosed with depression, anxiety, or suicidal ideation.

n = 97,616,995 patients

Results

uveitis patients were 78% more likely to develop depression

RR 1.78 (95% CI 1.76 to 1.80)

null 1

1.76

1.80

CI excludes the null - significant

More results

Of 97,616,995 patients in the database, 205,193 (0.24%) were diagnosed with uveitis and 29,270 with scleritis (0.029%).

The cumulative incidences of depression, anxiety, and suicidal ideation were 3,927; 4,936; and 457 per 100,000 patients with uveitis and 3,792; 5,064; and 357 per 100,000 patients with scleritis, respectively.

More results

The highest subgroup risks appeared in uveitis with glaucoma and depression (1.59, 1.55-1.62, p < 0.05) and scleritis with glaucoma and depression (1.47, 1.37-1.60, p < 0.05).

Risk ratios also showed a decreased risk of depression and anxiety in uveitis patients compared to patients with type 2 diabetes mellitus and rheumatoid arthritis.

“

Conclusion · 1 of 2

There is increased risk of depression, anxiety, or suicidal ideation in patients with uveitis or scleritis, including those with ocular complications or those prescribed systemic corticosteroids.

Conclusion · 2 of 2

These data highlight the need for physicians to consider a psychiatric review of systems into clinic visits for treatment of ocular inflammatory conditions.

Post

Incidence and Prevalence of Depression, Anxiety, and Suicidal Ideation in Patients with Uveitis and Scleritis in the TriNetX Database.

Uveitis was associated with a 78% higher risk of depression

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