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New research · Ophthalmology
Ocular immunology and inflammation · 14h
Cohort studyOcular immunology and inflammation · 2026

Incidence and Prevalence of Depression, Anxiety, and Suicidal Ideation in Patients with Uveitis and Scleritis in the TriNetX Database.

Rajit Agarwal, Daniel Lee, Israel Mendez Bermudez, Meghan K Berkenstock
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OphthalmologyCohort study

Uveitis was associated with a 78% higher risk of depression

Incidence and Prevalence of Depression, Anxiety, and Suicidal Ideation in Patients with Uveitis and Scleritis in the TriNetX Database.

Rajit Agarwal … Meghan K Berkenstock
Ocular immunology and inflammation · 2026
Purpose

To evaluate the incidence and prevalence of depression, anxiety, and suicidal ideation (suicidal ideation) in patients with uveitis and scleritis in the TriNetX US Collaborative Network.

Methods

A retrospective study was conducted using ICD-10 codes to identify patients with uveitis and scleritis who were then diagnosed with depression, anxiety, or suicidal ideation.

n = 97,616,995 patients
Results

uveitis patients were 78% more likely to develop depression

RR 1.78 (95% CI 1.76 to 1.80)
null 1
1.76
1.80
CI excludes the null - significant
More results

Of 97,616,995 patients in the database, 205,193 (0.24%) were diagnosed with uveitis and 29,270 with scleritis (0.029%).

The cumulative incidences of depression, anxiety, and suicidal ideation were 3,927; 4,936; and 457 per 100,000 patients with uveitis and 3,792; 5,064; and 357 per 100,000 patients with scleritis, respectively.

More results

The highest subgroup risks appeared in uveitis with glaucoma and depression (1.59, 1.55-1.62, p < 0.05) and scleritis with glaucoma and depression (1.47, 1.37-1.60, p < 0.05).

Risk ratios also showed a decreased risk of depression and anxiety in uveitis patients compared to patients with type 2 diabetes mellitus and rheumatoid arthritis.

“
Conclusion · 1 of 2

There is increased risk of depression, anxiety, or suicidal ideation in patients with uveitis or scleritis, including those with ocular complications or those prescribed systemic corticosteroids.

Conclusion · 2 of 2

These data highlight the need for physicians to consider a psychiatric review of systems into clinic visits for treatment of ocular inflammatory conditions.

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