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New research · Ophthalmology
Scientific reports · 15h
Randomized trialScientific reports · 2026

Comparative efficacy of eyelid cleansing wipes, hypochlorous acid, and saline for blepharitis-associated ocular surface disease: a randomized trial.

Ruijia Shi, Yihan Guo, Ao Li … Ying Jie
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OphthalmologyRandomized trial

Eyelid cleansing wipes gave lower symptom scores than saline in blepharitis

Comparative efficacy of eyelid cleansing wipes, hypochlorous acid, and saline for blepharitis-associated ocular surface disease: a randomized trial.

Ruijia Shi … Ying Jie
Scientific reports · 2026
Background

Blepharitis and meibomian gland dysfunction (meibomian gland dysfunction) commonly cause ocular surface symptoms, but comparative evidence for commonly used eyelid-cleansing strategies remains limited.

Methods

We compared the 4-week efficacy of preformulated eyelid cleansing wipes, hypochlorous acid-assisted cleansing, and saline-assisted cleansing in adults with blepharitis-associated ocular surface disease.

Results

wipes group had lower Week 4 symptom scores than saline group

MD -13.35 (95% CI -21.51 to -5.20)
null 0
-21.51
-5.20
CI excludes the null - significant
More results

The primary endpoint was the baseline-adjusted Week 4 visual analog scale (visual analog scale) score for the selected study eye in the full analysis set.

The overall between-group difference in baseline-adjusted Week 4 visual analog scale was significant (P = 0.007).

More results

Adjusted mean Week 4 visual analog scale values were 27.47 (95% CI, 22.18-32.76) in the wipe group, 33.16 (95% CI, 27.80-38.51) in the hypochlorous acid group, and 40.83 (95% CI, 34.93-46.72) in the saline group.

“
Conclusion

Confirmatory superiority over hypochlorous acid was not established, and sign-based secondary findings should be interpreted as supportive.

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