A systematic review and meta-analysis of the association of human papilloma virus infections with ocular surface squamous neoplasia.

We used the DerSimonian and Laird method to compute summary odds risk estimates in a random effects model.

The I 2 statistic was used to quantify heterogenicity.

The odds of Human Papilloma Virus was significantly higher in Ocular Squamous Surface Neoplasia lesions than benign lesions.

In subgroup analysis, the odds ratio was lower in studies from African countries (with high HIV prevalences) and countries closer to the equator.