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New research · Ophthalmology
Annals of nuclear medicine · 15h
Cohort studyAnnals of nuclear medicine · 2025

Diagnostic value of 18 F-FDG PET/CT in the follow-up of conjunctival melanoma.

Huan Ma, Chuangui Li, Qian Zhang … Daxi Xue
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OphthalmologyCohort study

PET/CT detects metastatic conjunctival melanoma with 94% overall accuracy in follow-up.

Diagnostic value of 18 F-FDG PET/CT in the follow-up of conjunctival melanoma.

Huan Ma … Daxi Xue
Annals of nuclear medicine · 2025
Purpose

To evaluate the diagnostic performance of 18 F-fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) in detecting metastatic conjunctival melanoma (conjunctival melanoma).

Methods

This retrospective study enrolled 67 patients with histopathologically confirmed conjunctival melanoma who underwent 18 F-FDG PET/CT for follow-up or suspected recurrence.

n = 67 patients
Results

how often the scan correctly told spread vs. no spread - higher is better

81.3%
Sensitivity
98%
Specificity
More results

The median interval from surgery to metastasis was 20.3 months (range 1-100 months), with 56.3% (9/16) occurring within the first postoperative year.

Lymph node metastases in conjunctival melanoma predominately occurred in ipsilateral regional nodes (90.1%), with rare bilateral involvement (9.1%).

More results

Standardized uptake value of metastatic lymph nodes, lung metastases, and liver metastases showed positive correlations with lesion size (p < 0.05 for all).

Among metastatic lymph nodes, 53.2% had a short-axis diameter < 10 mm, and 59.1% of bone metastases exhibited no abnormal CT density.

“
Conclusion

18 F-FDG PET/CT provides high diagnostic accuracy in detecting systemic metastases of conjunctival melanoma during follow-up assessments, particularly for small lymph nodes, early bone metastases, and uncommon sites.

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