Novel Risk Factors for Uveal Melanoma in Adolescent and Young Adult Patients: A Comprehensive Case-Control Analysis.

The prevalence of oculodermal melanocytosis ( P = 0.03) and family history of uveal melanoma ( P < 0.001) were significantly greater in uveal melanoma patients than in controls.

Uveal melanoma T-categories were as follows: 39% T1, 37% T2, 19% T3, and 5% T4.

Gene expression profiling was available in 64 patients and showed 59% class 1A, 19% class 1B, and 22% class 2 tumors.

The estimated 10-year metastasis-free progression rate and overall survival were 80% and 81%, respectively.