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New research · Ophthalmology
Ophthalmology science · 15h
Case-controlOphthalmology science · 2025

Novel Risk Factors for Uveal Melanoma in Adolescent and Young Adult Patients: A Comprehensive Case-Control Analysis.

Arina Nisanova, Susanna S Park, Aana Amin … Kavita K Mishra
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OphthalmologyCase-control

Family history of cutaneous melanoma linked to higher odds of uveal melanoma

Novel Risk Factors for Uveal Melanoma in Adolescent and Young Adult Patients: A Comprehensive Case-Control Analysis.

Arina Nisanova … Kavita K Mishra
Ophthalmology science · 2025
Purpose

To identify risk factors associated with uveal melanoma (uveal melanoma) in adolescents and young adults (adolescents and young adults).

Methods

Two hundred forty-seven uveal melanoma patients aged 13 to 45 treated with proton beam radiation therapy and 401 age- and sex-matched controls at a tertiary academic center.

n = 64 patients
OR = 3.06
Results
OR = 3.06
family history of skin melanoma triples the odds of eye melanoma
n = 64 patients
More results

The prevalence of oculodermal melanocytosis ( P = 0.03) and family history of uveal melanoma ( P < 0.001) were significantly greater in uveal melanoma patients than in controls.

Uveal melanoma T-categories were as follows: 39% T1, 37% T2, 19% T3, and 5% T4.

More results

Gene expression profiling was available in 64 patients and showed 59% class 1A, 19% class 1B, and 22% class 2 tumors.

The estimated 10-year metastasis-free progression rate and overall survival were 80% and 81%, respectively.

“
Conclusion · 1 of 2

This study identified several novel risk factors for uveal melanoma in adolescents and young adults and confirmed select established risk factors seen in uveal melanoma patients of all ages.

Conclusion · 2 of 2

To the best of our knowledge, this is the first explicit and comprehensive investigation of risk factors among a younger cohort and may help further elucidate uveal melanoma pathogenesis.

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