Early Peripapillary and Macular Microvascular Changes Following Ruthenium-106 Plaque Brachytherapy For Uveal Melanomas.
Peripapillary capillary density drops early after Ru-106 plaque brachytherapy for uveal melanoma.
Early Peripapillary and Macular Microvascular Changes Following Ruthenium-106 Plaque Brachytherapy For Uveal Melanomas.
To evaluate early peripapillary and macular microvascular changes following ruthenium-106 (Ru-106) episcleral plaque brachytherapy for uveal melanoma using optical coherence tomography angiography (optical coherence tomography angiography).
SUBJECTS: Twenty-four eyes of 24 patients with extramacular uveal melanoma treated with Ru-106 plaque brachytherapy at Cairo University Ocular Oncology Service.
Radial peripapillary capillary density fell significantly by 3 months, then held steady.
Mean best-corrected visual acuity (BCVA) declined from 0.44 ± 0.30 logMAR at baseline to 0.78 ± 0.72 at 6 months (p = .028).
Tumor height decreased significantly (p < .001).
By contrast, DCP density declined progressively and diffusely (45.17 ± 4.86% to 44.90 ± 4.87% at 3 months and 42.23 ± 3.68% at 6 months, p = .017), accompanied by significant foveal avascular zone enlargement (0.25 ± 0.12 to 0.34 ± 0.11 mm², p < .001).
Ru-106 brachytherapy induces early, subclinical microvascular injury detecTable by optical coherence tomography angiography.
radial peripapillary capillary changes are early and strongly correlate with optic nerve radiation dose and visual decline, SCP changes are localized, while DCP demonstrates progressive and generalized loss.
Tumor location influenced injury patterns, reflecting differential radiation exposure.
optical coherence tomography angiography may serve as a noninvasive biomarker for early detection and risk stratification of radiation-induced microvascular injury.