Rapidly progressive primary vitreoretinal lymphoma with optic disc involvement and retinal detachment.

OBSERVATIONS: A 42-year-old woman presented with a 1-week history of temporal visual field loss in the right eye and was referred to our hospital for suspected retinal detachment.

Fundus examination revealed vitreous cells, retinal hemorrhages, retinal vasculitis, and extensive subretinal fluid.

Optical coherence tomography showed preretinal hyperreflective deposits with a level-like appearance.

Diagnostic vitrectomy identified a monoclonal B-cell population with an elevated interleukin-10/-6 ratio and clonality of the immunoglobulin heavy-chain gene, confirming primary vitreoretinal lymphoma.