Evaluation of the Expression of Small Extracellular Vesicle Markers and Their Cargo in Treatment-Naïve…

StudyTranslational vision science & technology· Jan 2026

Evaluation of the Expression of Small Extracellular Vesicle Markers and Their Cargo in Treatment-Naïve Retinoblastoma Tumor Tissues.

Saumya Jakati, Tirupathi Rao Mocherla, Rani Pallavi … Swathi Kaliki

Ocular OncologyStudyQ1IF 2.8

TSG101 extracellular vesicle marker was expressed in 92% of retinoblastoma tumors.

Evaluation of the Expression of Small Extracellular Vesicle Markers and Their Cargo in Treatment-Naïve Retinoblastoma Tumor Tissues.

Saumya Jakati … Swathi Kaliki

Translational vision science & technology · Jan 2026 · Q1 in Ophthalmology

Purpose

To evaluate the expression of small extracellular vesicle (sEV)-specific markers in retinoblastoma (retinoblastoma) tumor tissue and to identify the retinoblastoma-specific extracellular cargo as biomarker.

Methods

Twenty-five treatment-naïve, unilateral retinoblastoma were included in the study from ophthalmic pathology achieves during January 2020 to December 2022.

n = 11

Results

expression of a tumor-linked marker was found in almost all tumors

44%

CD63

92%

TSG101

More results

CD81 was the least expressed.

Of the sEV cargo, HIF1a (n = 22, 88%) followed by KAT2B (n = 21 [84%]) showed increased expression in tumor cells with no expression in normal retina.

Vascular endothelial growth factor A was seen in 48% of cases and was expressed in normal retina.

All the markers showed heterogenous expression in the tumor.

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Conclusion · 1 of 2

Although sEV markers are expressed in tumor microenvironment, their expression is heterogenous in tumors. Of the EV markers, tetraspanin CD63 was predominantly expressed in tumor tissues as compared with CD9 and CD81.

Conclusion · 2 of 2

Among the previously identified EV cargo, HIF1a and KAT2B were found to be expressed in retinoblastoma tumors, indicating their potential as biomarkers.

Evaluation of the Expression of Small Extracellular Vesicle Markers and Their Cargo in Treatment-Naïve Retinoblastoma Tumor Tissues.

Evaluation of the Expression of Small Extracellular Vesicle Markers and Their Cargo in Treatment-Naïve Retinoblastoma Tumor Tissues.

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